Humans Were Injected: BREAKTHROUGH Age Reversal For Every Tissue

Life Biosciences just dosed the first human patient with ER-100 — an OSK gene therapy built from three Yamanaka factors, designed to reprogram old cells back toward a younger state. The first target is the eye. But the real implication is much bigger: this method appears to work on every tissue type it has been tried on.

If this first eye trial comes back safe, it could be the first domino in a much larger age-reversal wave: eye, liver, brain, skin, muscle, heart, kidney, blood vessels — potentially every tissue in the body.

This episode reveals the tidal wave of companies racing toward human trials using the same basic strategy: epigenetically reprogramming old cells so they behave young again. Billions of dollars are pouring into this from Jeff Bezos, Sam Altman, Brian Armstrong, Peter Thiel, and the biggest names in longevity biotech.

We walk through who they are, what they are trying to cure, why the eye came first, what worked in mice and monkeys, why NewLimit is going after liver rejuvenation, and whether the cheap pill version could be right behind the expensive gene therapy.

Bottom line: real age reversal is now in a human trial.

LONGEVITY LATTE PRE-ORDER:
[INSERT LINK]

TIMESTAMPS
0:00 – Cold Open
1:40 – What Just Entered a Human Eye
2:35 – ER-100, OSK, and the Yamanaka Factors
4:45 – NewLimit and Liver Rejuvenation
8:00 – The Age-Reversal Company Wave
11:25 – The Cheap Pill Version
13:35 – The Hard Limit Argument

SOURCES & LINKS
Life Biosciences first patient dosed:
ER-100 ClinicalTrials.gov:
Life Biosciences FDA IND clearance:
Life Biosciences primate data:
Lu et al. 2020, Nature:
Yamanaka Nobel Prize:
David Sinclair on first patient dosed:
David Sinclair, Lifespan S2:
NewLimit $435M raise:
NewLimit:
Jacob Kimmel / NewLimit update:
Altos Labs:
Retro Biosciences:
YouthBio:
Rejuvenate Bio:
Turn Bio:
Shift Bioscience:
Sinclair chemical reprogramming paper:
Previous LSN episode:
Peter Fedichev critique:
Serial cloning paper:
Derya Unutmaz biosingularity tweet:

TOPICS COVERED
age reversal, epigenetic reprogramming, cellular reprogramming, Yamanaka factors, OSK, ER-100, Life Biosciences, David Sinclair, optic neuropathy, glaucoma, retina, optic nerve regeneration, gene therapy, partial reprogramming, NewLimit, Brian Armstrong, Jacob Kimmel, Peter Thiel, Altos Labs, Jeff Bezos, Retro Biosciences, Sam Altman, YouthBio, Rejuvenate Bio, Turn Bio, Shift Bioscience, chemical reprogramming, anti-aging pill, longevity biotech, regenerative medicine, DNA mutations, cancer risk, biosingularity, healthspan, lifespan

LATEST EXCLUSIVE INTERVIEW:

Disclaimer: This video is educational and informational only and does not constitute medical advice. Consult a qualified clinician before making health or treatment decisions.

EXCLUSIVE INTERVIEWS & BONUS CONTENT
Patreon:
YT Membership:

PRODUCTION CREDITS
Executive Producer – Keith Comito @Retromancers @Retromancers
Host, Producer, Writer – Emmett Short @emmettshort @@emmettshort